Blar i forfatter "Erdélyi, Máté"

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    • Fluorinated captopril analogues inhibit metallo-β-lactamases and facilitate structure determination of NDM-1 binding pose 

      Kondratieva, Alexandra; Palica, Katarzyna; Frøhlich, Christopher; Rolfsnes Hovd, Rebekka; Leiros, Hanna-Kirsti S.; Erdélyi, Máté; Bayer, Annette (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-10)
      Bacterial resistance to the majority of clinically used β-lactam antibiotics is a global health threat and, consequently, the driving force for the development of metallo-β-lactamase (MBL) inhibitors. The rapid evolution of new MBLs calls for new strategies and tools for inhibitor development. In this study, we designed and developed a series of trifluoromethylated captopril analogues as probes for ...

    • Halogen Bonding: An Odd Chemistry? 

      Turunen, Lotta; Hansen, Jørn H; Erdélyi, Máté (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-03)
      Halogen bonding is a flourishing field of research, but has for long been little recognized. The same goes for its scientific hero, Odd Hassel, who laid the foundations for all current developments. The crystallographic observation of halogen−oxygen interatomic distances shorter than the sum of the van der Waals radii of the involved atoms, and the interpretation of this phenomenon as a charge-transfer ...

    • Metallo-β-Lactamase Inhibitor Phosphonamidate Monoesters 

      Palica, Katarzyna; Vorácová, Manuela; Skagseth, Susann; Andersson Rasmussen, Anna; Allander, Lisa; Hubert, Madlen; Sandegren, Linus; Leiros, Hanna-Kirsti S.; Andersson, Hanna; Erdélyi, Máté (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-25)
      Being the second leading cause of death and the leading cause of disability-adjusted life years worldwide, infectious diseases remain-contrary to earlier predictions-a major consideration for the public health of the 21st century. Resistance development of microbes to antimicrobial drugs constitutes a large part of this devastating problem. The most widely spread mechanism of bacterial resistance ...